ePlasty: Vol. 18
Skin Grafting in Pyoderma Gangrenosum
Marco Romanelli, MD, PhD, Agata Janowska, MD, Teresa Oranges, MD, and Valentina Dini, MD, PhD

Department of Dermatology, University of Pisa, Pisa, Italy

Correspondence: romanellimarco60@gmail.com
Keywords: pyoderma gangrenosum, allograft, pathergy, adalimumab, chronic wounds


A 75-year-old woman presented with multiple painful necrotic ulcers of the lower leg lasting since 2 months (Fig 1). Doppler studies of the venous and arterial systems were within normal limits. The diagnosis of pyoderma gangrenosum (PG) was based on clinical and histopathological presentation showing a dermal aspecific neutrophilic infiltrate (Fig 2).

Figure 1. Wound bed status of pyoderma gangrenosum at baseline.
Figure 2. Tissue biopsy of pyoderma gangrenosum showing aspecific dermal neutrophilic infiltrate.

Current blood screening with complete blood cell count, renal and liver function tests, lipid profile, the serum electrolytes, serum electrophoresis, clinical antibody profile, se .......