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  • Reduction of a Multidrug-Resistant Pathogen and Associated Virulence Factors in a Burn Wound Infection Model: Further Understanding of the Effectiveness of a Hydroconductive Dressing

ePlasty: Vol. 14
Reduction of a Multidrug-Resistant Pathogen and Associated Virulence Factors in a Burn Wound Infection Model: Further Understanding of the Effectiveness of a Hydroconductive Dressing
Bonnie C. Carney, BS,a Rachel T. Ortiz, MS,a Rachael M. Bullock,a Nicholas J. Prindeze, BS,a Lauren T. Moffatt, PhD,a Martin C. Robson, MD,b and Jeffrey W. Shupp, MDa,c

aFirefighters’ Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC; bDepartment of Surgery, University of South Florida, Tampa; and cThe Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC

Correspondence: jeffrey.w.shupp@medstar.net
Keywords: infection, burn, wounds, dressings, virulence factors

Objective: Drawtex's ability to remove pathogens and associated virulence factors has been demonstrated in vitro. A model of burn wound infection was used to characterize the in vivo impact of this dressing on infection and wound healing. Methods: Paired burn wounds were created on the dorsum of Sprague Dawley rats and were inoculated with methicillin-resistant Staphylococcus aureus (MRSA). Animals were divided into 2 groups, half with wounds that received experim .......