ePlasty: Vol. 19
Randomized Comparison of Hypochlorous Acid With 5% Sulfamylon Solution as Topical Therapy Following Skin Grafting
Kevin N. Foster, MD, MBA, FACS, K. J. Richey, BSN, RN, J. S. Champagne, MA, RN, and M. R. Matthews, MD, FACS

The Arizona Burn Center at Maricopa Integrated Health System Phoenix


Correspondence: kevin_foster@dmgaz.org
Keywords: hypochlorous acid, Sulfamylon, skin graft, healing, pain

Objective: Infections are a serious complication of thermal injury. Excision and grafting have led to a decrease in incidence, but to ensure successful skin grafting, antimicrobial irrigants are frequently utilized to prevent infection. A safe, efficacious, and cost-effective irrigant capable of preventing infections would be a valuable adjunctive therapy. The objectives of this study were to determine whether the test article was noninferior to current therapy in controlling infection and reducing postoperative pain in patients with skin graft. Methods: Patients with burns requiring skin grafting were randomized to hypochlorous acid or 5% Sulfamylon solution as topical dressings postoperatively. Inclusion criteria included thermal injury 20% or more total body surface area requiring excision and autografting, and age 18 years or more. Exclusion criteria included pregnant females, chlorine sensitivity, and electrical/chemical/cold injuries. The following ou .......