ePlasty: Vol. 18
Brooke-Spiegler Syndrome
Waseem Mohiuddin, BS,a Jake Laun, MD,b and Wayne Cruse, MDb

aDivision of Plastic Surgery, Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pa; and bDepartment of Plastic Surgery, Morsani College of Medicine, Tampa, Fla


Correspondence: jlaun@health.usf.edu
Keywords: Brooke-Spiegler syndrome, trichoepithelioma, spiradenoma, cylindroma, adnexal tumors

DESCRIPTION

A 52-year-old woman presented to the cutaneous clinic with multiple firm, rubbery, flesh-colored papules localized to the face. Biopsy confirmed trichoepitheliomas. Because of clinical and histological manifestations, the patient was suspected to have Brooke-Spiegler syndrome. Patient stated that she had had these lesions since she was a teenager and had had them biopsied in the past, with some shown to be basal cell carcinomas.

QUESTIONS

1. What is Brooke-Spiegler syndrome?

2. How is Brooke-Spiegler syndrome diagnosed?

3. What are the treatment options for Brooke-Spiegler syndrome?

4. What is the prognosis for Brooke-Spiegler syndrome?

DISCUSSION

Brooke-Spiegler syndrome is a  .......