ePlasty: Vol. 10
Induction of Angiogenesis and Neovascularization in Adjacent Tissue of Plasma-Collagen–Coated Silicone Implants
Andrej Ring, MD,a Stefan Langer, MD,a Daniel Tilkorn, MD,a Ole Goertz, MD,a Lena Henrich, MS,a Ingo Stricker, MD,b Hans-Ulrich Steinau, MD,b Lars Steinstraesser, MD,b and Joerg Hauser, MDb

aDepartment of Plastic and Hand Surgery, University Hospital Bergmannsheil Bochum, Germany; and bInstitute of Pathology, Ruhr University Bochum, Germany

Correspondence: andrej.ring@ruhr-uni-bochum.de

Objective: Formation of encapsulating, avascular fibrous tissue is deemed to decrease implant's biocompatibility and versatility. We investigated whether plasma-mediated collagen coating possesses the ability to enhance neovascularization in the vicinity of silicone implants. Methods: Plasma-treated collagen-I–coated silicone samples were placed into the dorsal skinfold chambers of female balb/c mice (n = 10). Conventional silicone served as control (n = 10). Intravital microscopy was performed within implant's surrounding tissue on days 1, 5, and 10. Functional vessel density, intervascular distance, vessel diameter, microvascular permeability, red blood cell velocity, and leukocyte-end .......