ePlasty: Vol. 13
Does the Application of Incisional Negative Pressure Therapy to High-Risk Wounds Prevent Surgical Site Complications? A Systematic Review
Michael J. Ingargiola, BS, Lily N. Daniali, MD, and Edward S. Lee, MD

University of Medicine and Dentistry of New Jersey, Department of Surgery, Division of Plastic Surgery, Newark, NJ

Correspondence: leee9@umdnj.edu

Keywords: incisional wound therapy, INPWT, negative pressure wound therapy, NPWT, surgical site complications, topical negative pressure

Purpose: The application of incisional negative pressure wound therapy (INPWT) to clean, closed surgical incisions is a growing clinical practice. A systematic review was conducted to evaluate the effect of INPWT on surgical sites healing by primary intention. The primary outcomes of interest are incidence of complications (infection, dehiscence, seroma, hematoma, skin necrosis, or blistering). Methods: Two independent reviewers performed a search of the Ovid MEDLINE and EMBASE databases from 2006 to 2012 for published articles. Supplemental searches were performed using reference lists and conference proceedings. Studies were selected for inclusion based on predetermined inclusion and exclusion criteria. Data extraction regarding study quality, demographic and clinical characteristics, and outcomes was performed independently, and data on the incidence of infection was combined using a fixed-effects meta-analysis model. R .......