ePlasty: Vol. 8
Silk: A Potential Medium for Tissue Engineering
Cassandra Sobajo, MSc,a Farhad Behzad, MSc, PhD,a Xue-Feng Yuan, MSc, PhD,b and Ardeshir Bayat, BSc (Hons), MBBS, PhD, MRCSa

aPlastic & Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, the University of Manchester, Manchester, M1 7DN, UK; and bBiochemical Physics, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, M1 7DN, UK

The authors have no conflicts of interest.

Correspondence: ardeshir.bayat@manchester.ac.uk

Objective: Human skin is a complex bilayered organ that serves as a protective barrier against the environment. The loss of integrity of skin by traumatic experiences such as burns and ulcers may result in considerable disability or ultimately death. Therefore, in skin injuries, adequate dermal substitutes are among primary care targets, aimed at replacing the structural and functional properties of native skin. To date, there are very few single application tissue-engineered dermal constructs fulfilling this criterion. Silk produced by the domestic silkworm, Bombyx mori, has a long history of use in medicine. It has recently been increasingly investigated as a promising biomaterial for dermal constructs. Silk contains 2 fibrous proteins, sericin and fibroin. Each one exhibits unique mec .......