ePlasty: Vol. 11
Wound Healing Trajectories to Determine Pressure Ulcer Treatment Efficacy
Wyatt G. Payne, MD,a,b Rajat Bhalla, BS, MS,a,b Donald P. Hill, PharmD,c Yvonne N. Pierpont, MD,a,b and Martin C. Robson, MDb

aInstitute for Tissue Regeneration, Repair, and Rehabilitation, Bay Pines VA Healthcare System, Bay Pines, Florida; bDivision of Plastic Surgery, University of South Florida, Tampa, Florida; and cProfil Institute for Clinical Research, Inc., Chula Vista, California


Correspondence: Wyatt.Payne@med.va.gov

Background: Wound healing trajectories (percent healing vs time) provide a dynamic picture of the decrease in wound burden over the entire continuum of the healing process. Trajectories can be robustly compared using survival statistics methodology. Improvement in healing can be determined by shifting the curve from “impaired” healing toward “ideal” healing. Although this concept of shifting the curve “to the left” has been demonstrated in acute incisional healing depicted by the gain in tensile strength, and in other chronic wounds, it has not been utilized for chronic pressure ulcers. Methods: Wound healing trajectories were constructed for 211 patients enrolled in 8 separate randomized clinical trials for grade III and IV pressure ulcers. Trajectories were constructed for patients achieving ≥90% or more healing wit .......