ePlasty: Vol. 11
Telomere Dynamics in Keloids
Mark Granick, MD,a Masayuki Kimura, MD, PhD,b Soyeon Kim, ScD,c Lily Daniali, MD,a Xiaojian Cao,b Utz Herbig, PhD,d and Abraham Aviv, MDb

aDivision of Plastic Surgery, Department of Surgery, bCenter of Human Development and Aging, cDepartment of Preventive Medicine and Community Health, and dDepartment of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark


Correspondence: avivab@umdnj.edu

Objective: Little is known about telomere dynamics in keloids. As keloid formation is dependent on cell replication, in theory telomeres should be shorter in keloids than in normal skin. We examined this concept in the present study. Methods: We measured by Southern blot analysis telomere length in keloids and in adjacent normal skin of 16 individuals. When available, we also measured telomere length in blood (leukocytes) and subcutaneous fat. Results: Telomere length was highly variable among individuals but highly correlated among tissues (cells) within the individual. The mean telomere length in the keloids was longer than that in the adjacent normal skin and displayed a length gradient, with the mean length of telomeres shorter just below the epidermis and longer at .......