ePlasty: Vol. 11
Near-Infrared Irradiation Nonthermally Induces Long-lasting Vasodilation by Causing Apoptosis of Vascular Smooth Muscle Cells
Yohei Tanaka, MD, PhD, Kiyoshi Matsuo, MD, PhD, and Shunsuke Yuzuriha, MD, PhD

Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine, Matsumoto, Japan


Correspondence: kmatsuo@shinshu-u.ac.jp

Background: Moderate sunburn after prolonged sun exposure is thought to cause long-lasting inflammatory vasodilation due to thermal and ultraviolet radiation from the sun. We previously reported that near-infrared irradiation that simulates solar near-infrared can penetrate the skin and nonthermally affect the dermis, superficial muscles, and other tissues. To clarify the possible effect of near-infrared on long-lasting vasodilation, we evaluated how near-infrared affects subcutaneous vascular smooth muscle cells in rats. Methods: The central back tissues of rats were irradiated with a near-infrared device that simulates solar radiation, which has specialized contact cooling to avoid thermal effects. The total energy emitted was equivalent to approximately 8.75 hours of sunbathing in North America. Histological evaluation was performed on the subdermal plexus over the panniculus carnosus muscle of the near-infrared–irradiated rats at postirradiation days 7, 30, 60, and 90, and compared with nonirradiated controls. The vascular smooth muscle cells were evaluated by the transferase-mediated dUTP nick-end labeling assay and staining with an anti-smooth muscle actin antibody. Results: There was no evidence of inflammatio .......