ePlasty: Vol. 11
Use of Platelet Rich Plasma Gel on Wound Healing: A Systematic Review and Meta-Analysis
Marissa J. Carter, PhD, MA,a Carelyn P. Fylling, MSN, RN, CWS, CLNC,b and Laura K. S. Parnell, MSc, CWSc

aStrategic Solutions, Inc, Cody, WY; bCytomedix, Inc, Gaithersburg, MD; and cPrecision Consulting, Missouri City, TX

Correspondence: l-parnell@earthlink.net

Objective: Autologous platelet rich plasma is an advanced wound therapy used in hard-to-heal acute and chronic wounds. To better understand the use and clinical outcomes of the therapy, a systematic review of the published literature in cutaneous wounds was performed. Methods: Electronic and hand searches for randomized controlled trials and comparative group studies using platelet rich plasma therapy in cutaneous wounds and published over the last 10 years was conducted. Eligible studies compared the treatment to standard care or other interventions. All citations were screened and eligible studies were assessed for validity, quality, and bias using accepted scoring methods. The primary outcomes were effect of platelet rich plasma and control wound care on wound healing and related healing measurements. Secondary outcomes related to healing such as infection, pain, exudate, adverse events, and quality of life were also considered. The meta-analysis utilized appropriate statistical methods to determine the overall treatment effect on chronic and acute wound healing and infection.  .......