ePlasty: Vol. 14
Use of Bacteria- and Fungus-Binding Mesh in Negative Pressure Wound Therapy Provides Significant Granulation Tissue Without Tissue Ingrowth
Malin Malmsjö, MD, PhD,a Sandra Lindstedt, MD, PhD,b Richard Ingemansson, MD, PhD,b and Lotta Gustafsson, MD, PhDa

aDepartments of Ophthalmology; and bCardiothoracic Surgery, Lund University and Skåne University Hospital, Lund, Sweden

Correspondence: malin.malmsjo@med.lu.se
Keywords: blood flow, experimental surgery, negative pressure wound therapy, wound contraction, wound dressing, wound healing

Objective: Bacteria- and fungus-binding mesh traps and inactivates bacteria and fungus, which makes it interesting, alternative, and wound filler for negative pressure wound therapy (NPWT). The aim of this study was to compare pathogen-binding mesh, black foam, and gauze in NPWT with regard to granulation tissue formation and ingrowth of wound bed tissue in the wound filler. Methods: Wounds on the backs of 8 pigs underwent 72 hours of NPWT using pathogen-binding mesh, foam, or gauze. Microdeformation of the wound bed and granulation tissue formation and the force required to remove the wound fillers was studied. Results: Pathogen-binding mesh produced more granulation tissue, leukocyte infiltration, and tissue disorganization in the wound bed than gauze, but less th .......